Argininosuccinate Synthetase Catalyzes |Get Solution

Author: Client Uploads

May 21st, 2021

The enzyme argininosuccinate synthetase catalyzes the formation of argininosuccinate from citrulline and aspartate in an ATP dependent manner ( reaction shown below):Citrulline + ATP+L-Asp? Argininosuccinate +AMP+PPiIn a test tube, the enzyme-catalyzed reaction is readily reversible , yet in a cell the enzyme-catalyzed reaction is highly irreversible.Provide a detailed thermodynamic/ chemical explanation as to why this reaction is largely irreversible in a cell but not in a test tube.

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