BIOT 645 Insulin Detemir Discussion

BIOT 645 Insulin Detemir Discussion
Identify a protein of interest that your company will be manufacturing (e.g. a HER2 targeted antibody). The choice of protein is important, so please read ahead to understand the assignments in week 10 and week 12. In choosing a protein, please choose one that is already manufactured by another company in real life (though it will be “new” to your company), one for which there is published literature so you can find details on the production process and please do not choose one of the proteins that we have looked as so far in class.
Identify an appropriate model system and expression system in which your protein of interest will be expressed (e.g. CHO cells with double selection procedure)
Identify an appropriate biomanufacturing process for your protein using your model and expression system (e.g. Fig 3 in
Write a paper in prose (not outline) of up to five pages in length describing : The upstream and downstream processing steps involved in manufacturing the protein [including: what facilities / equipment are needed, what are the critical steps, how will the product be separated and purified?
The protein of Interest in “INSULIN detemir”
Insulin detemir, sold under the brand name Levemir among others, is a long-acting insulin used to treat both type 1 and type 2 diabetes.[6] It is used by injection under the skin.[6] It is effective for up to 24 hours.[6]
Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain.[6] Use in pregnancy and breastfeeding appears safe.[7] It works by increasing the amount of glucose that tissues take in and decreasing the amount of glucose made by the liver.[6]
Insulin detemir was approved for medical use in the European Union in June 2004, and in the United States in June 2005.[5][6][8] It is on the World Health Organization’s List of Essential Medicines.[9] In 2019, it was the 121st most commonly prescribed medication in the United States, with more than 5 million prescriptions.
Medical use
It is used to treat both type 1 and type 2 diabetes.[6] A recent Cochrane systematic review[12] also compared the effects of insulin detemir to NPH insulin and other insulin analogues (insulin glargine, insulin degludec) in both children and adults with Type 1 diabetes. With respect to blood sugar management, it appears to work better than NPH insulin, however this finding was inconsistent across included and previous studies.[6][12] In the same systematic review no other clinically significant differences were found between different insulin analogues in either adults nor children.[12]
BIOT 645 Insulin Detemir Discussion
Side effects
Common side effects include low blood sugar, allergic reactions, pain at the site of injection, and weight gain.[6] Use in pregnancy and breastfeeding appears safe.[7]
It is an insulin analogue in which a fatty acid (myristic acid) is bound to the lysine amino acid at position B29. It is quickly absorbed after which it binds to albumin in the blood through its fatty acid at position B29. It then slowly dissociates from this complex.
Society and culture
On 13 June 2009, the U.S. Food and Drug Administration (FDA) issued a public health advisory for insulin determir after learning that 129,000 stolen vials reappeared and were being sold in the U.S. market. The FDA warned that the stolen vials “may not have been stored and handled properly and may be dangerous for patients to use.” The stolen vials were identified as lots XZF0036, XZF0037, and XZF0038.

Don't use plagiarized sources. Get Your Custom Essay on
BIOT 645 Insulin Detemir Discussion
Get a 15% discount on this Paper
Order Essay
Quality Guaranteed

With us, you are either satisfied 100% or you get your money back-No monkey business

Check Prices
Make an order in advance and get the best price
Pages (550 words)
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know that being a student these days is hard. Because of this, our prices are some of the lowest on the market.

Instead, we offer perks, discounts, and free services to enhance your experience.
Sign up, place your order, and leave the rest to our professional paper writers in less than 2 minutes.
step 1
Upload assignment instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
Get personalized services with My Paper Support
One writer for all your papers
You can select one writer for all your papers. This option enhances the consistency in the quality of your assignments. Select your preferred writer from the list of writers who have handledf your previous assignments
Same paper from different writers
Are you ordering the same assignment for a friend? You can get the same paper from different writers. The goal is to produce 100% unique and original papers
Copy of sources used
Our homework writers will provide you with copies of sources used on your request. Just add the option when plaing your order
What our partners say about us
We appreciate every review and are always looking for ways to grow. See what other students think about our do my paper service.
IT, Web
A great job on my paper!! I really appreciate this!!
Customer 452885, January 30th, 2023
Social Work and Human Services
Customer 452587, July 28th, 2021
Customer 452813, June 28th, 2022
Business and administrative studies
Thank you very much for your help.
Customer 452861, September 16th, 2022
This has everything that was in the rubric. Thank you!
Customer 452707, May 29th, 2022
Writer went above and beyond. Can't believe how much work they put in for the price.
Customer 452707, July 10th, 2022
Customer 452813, June 25th, 2022
Everything was done thoroughly and with care. Awesome job!!!
Customer 452453, April 10th, 2021
Customer 452813, September 20th, 2022
Great job on the paper!
Customer 452885, December 28th, 2022
Business and administrative studies
Customer 452813, June 30th, 2022
Customer 452813, July 9th, 2022
Enjoy affordable prices and lifetime discounts
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Order Now Order in Chat

Start off on the right foot this semester. Get expert-written solutions at a 20% discount