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speaker notes ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ON speaker notes I need detailed speaker notes for each slide. Use the references to further elaborate. please keep in mind this is a scientific presentation and not a low grade school presentation. provide details from references.speaker notes attachment_1 DRUG: KYMRIAH (TISAGENLECLEUCEL) MANUFACTURER: NOVARTIS INTERNATIONAL AG LOCATION: BASEL, SWITZERLAND DISEASES/DISORDERS TREATED ? Tisagenlecleucel is the real name of the drug but it is marketed as KYMRIAH (Pharma US, 2017). ? It is used to treat the B-cell acute lymphoblastic leukemia cancer (B-cell all). ? In regard to mechanism of action, KYMRIAH reprograms the T-cells of a patient with transgene encoding of chimeric antigen receptor (CAR). ? The CAR then identifies and destroy any CD19-expressing tumor, malignant or normal cells. The CAR is a single-chain antibody with the ability to recognize CD19. CAR is fused in the intracellular signaling domains – CD3 zeta and 4-1BB (CD137) (Pharma US, 2017). ? The ? The CD3 zeta is responsible for malignant destruction and initiation of T-cell activation. ? The 4-1BB enhances the sensitivity, persistence and expansion of KYMRIAH. ? Once the CD-19 expressing cell is identified, the CAR signals T-cells to expand, activate and work on the destruction of the malignant cell. PRIMARY RESEARCH ? KYMRIAH was once used in the study B2202 with 68 subjects. ? The major adverse effects noted in the study was cytokine release syndrome (CRS). ? Hemophagocytic lymphohistiocytosis (HLH) was also noted, with other side effects occurring due to CRS. ? Grade 3 and 4 CRS was noted among 32 individuals. This was 47% of the sample (Pharma US, 2017). ? CRS resulted in no deaths. ? Other neurological toxicities included delirium, ancephalopathy, seizure, hallucinations, mental status changes, cognitive disorder, dysphagia, and somnolence. ? Another study revealed that KYMRIAH increased in the body with time. ? After 28 days from infusion, KYMRIAH was found to be 44% in the patient’s bone marrow (Pharma US, 2017). ? The product was found to be 67% and 69% respectively for 3 and 6 months after infusion. INTELLECTUAL PROPERTY STATUS ? The product, KYMRIAH, is patented by Novartis and the University of Pennsylvania. ? The patent was effected in 2012. ? The CAR-T technology is patented by Memorial Sloan Kettering Cancer Center whereas the KYMRIAH technology using the CAR-T is patented by Novartis (BioPharm International, 2017). ? The product is thus independently prepared by Novartis and is patient based – based on the patient’s own T-blood cells. DEVELOPMENT GENETICS ? The safety of KYMRIAH is only ascertained among the pediatric patient and those below 25 years of age. is also no evidence whether the drug can be used for geriatric use – those above 65 years of age (Pharma US, 2017). ? There ? There is also no evidence whether KYMRIAH is present in breastfeeding milk or not. ? KYMRIAH was considered specialized for the young from a study involving 107 patients. speaker notes ? The study involved infusing 63 patients with the KYMRIAH, in which 52 of them achieved a CR/CRi which was MRD-negative. PLATFORM TECHNOLOGY ? KYMRIAH ? It is basically utilizes the antigen platform technology. uses the chimeric antigen receptor (CAR) for T cells. ? The dosage is based on the weight of the patient where those below 50kg are receive 0.2 to 5.0 *10^6 CAR positive T cells. ? Those above 50kg are given 0.1-2.5*10^8 (Pharma US, 2017). ? The KYMRIAH also utilizes the anti-CD19 chimeric antigen receptor (CAR) ? The CAR is composed of single chain antibody fragments. ? The technology also uses the anti-CD3/CD28 beads coated with antibodies. ? This is used to activate the KYMRIAH. HOST CELLS AND UPSTREAM PRODUCTION DETAILS ? The patient’s blood is first drawn using a process called “leukapheresis.” ? The main form of drawing blood is using a catheter (Pharma US, 2017). ? The magnocellular cells of the sample is then enriched for T cells. ? The next step is transducing the sample with anti-CD3/CD28 antibodies coated beads. ? The next step is to culture the T-cells and expand them (Pharma US, 2017). ? They ? The ? It are then cleaned and used to formulate a suspension. suspension is then cryopreserved and tested using sterility tests. is then stored in frozen form for easy transportation and to avoid contamination. CELL BANK SYSTEM(S) UTILIZED ? The cell bank system for KYMRIAH utilizes the DMSO solution, which helps in preserving the product until usage. ? The KYMRIAH is typically place in plastic bags, which are doubled to enhance the protection of the product from contamination and bacterial activity. ? The 10% DMSO requires that the product is thawed and diluted to avoid the side effects of DMSO, but this does not occur in KYMRIAH as it can result in negative results. DOWNSTREAM PRODUCT RECOVERY AND PURIFICATION ? After its making, KYMRIAH is frozen and stored in frozen form. ? It is stored in a patient specific bag, labeled and sealed specifically with the patient’s product. ? The product is further put inside another packaging bad and further labeled to reflect patient information (Pharma US, 2017). ? It is then transported in the frozen form to the patient. ? Upon receipt, the physician is expected to confirm whether both bags housing the product read the patient’s name and then thaw the medicine before administration. PRODUCT FORMULATION ? The product contains T cells, monocytes, B cells, and NK cells. ? It also contains Plasma Lyte A at 31.25%v/v, 5% dextrose at 31.25%, sodium chloride (Pharma US, 2017). ? It also has 10% of dextran 40 (LMD)/5% dextrose and 20% of 25% human serum albumin (HSA). ? The product also has Cryoserv dymethylsulfoxide (DMSO) at 7.5% (Pharma US, 2017). ? One single dose of KYMRIAH contains at least 2.5*10^8 CARpositive T cells. ADVANCED STRATEGIES USED (PAT, QBD, CONTINUOUS PROCESSING) ? The fact that the FDA approved KYMRIAH for use in the US healthcare sector and the EU is in the process of approving, it shows that it utilizes the best technologies for production. ? KYMRIAH uses PAT to ensure that the quality of the product is maintained and is high quality. speaker notes ? On the other hand, QBD is used to ensure that the quality of the product is maintained through production as well as during and after delivery. ? Freezing ? Packing ? It of the KYMRIAH suspension is one of the QBD strategies. the product in double patient-addressed bags is also a quality precaution. is not clear whether continuous process is used in KYMRIAH. ACTIVE SUBSTANCE TESTING, PRODUCT STABILITY, BIO-BURDEN ? Active substance testing is usually carried out to determine the specific dosage of the patient. concentration of the T-cells in comparison to the patient’s weight determines the patient’s dosage. ? The ? The product has been considered stable when in frozen form, which necessitates that it is stored in this form. ? The bio-burden associated with the product is limited by freezing the product through out its handling and delivery. ? This ensures that microorganisms including bacteria are not able to grow or be active in the environments surrounding the medicine. CLINICAL TRIALS AND FDA APPROVAL PROCESS ? The clinical trials were conducted under varying environments and conditions. ? The trial utilized 68 patients with refractory or relapsed (R/R) B-cell ALL. ? They received CAR-positive T cells. The dosage for all the patients was weight based (BioPharm International, 2017). were two categories for administering the treatment – those below 50kg and those above 50kg (Pharma US, 2017). ? There ? The major adverse side effect was Cytokine release syndrome that appeared to be 79%. Hypogammaglobulinemia occurred 43%, pyrexia occurred 40% while infections-pathogen unspecified appeared to be 41% (Pharma US, 2017). ? Eleven death were accounted for, seven were disease related and others died due to abdominal compartment syndrome and progressive leukemia. ANNUAL SALES REVENUE, MARKET SHARE ? One dose of KYMRIAH costs $475,000 (BioPharm International, 2017). ? However, Novartis have stated that they will not charge individuals who do not respond on the drug. ? Novartis have gained at least $118,750,000 from the sale of KYMRIAH since it was discovered. ? KYMRIAH has a large market share worldwide (Novartis, 2018). speaker notes ? This is based on the fact that it is the first ever CAR-T therapy and there are many patients that need the medication (Pharma US, 2017). ? The ? The drug was approved by the US FDA on 30, August 2017 (Novartis, 2018). EU is still in the process of verifying the effectiveness of KYRIAH through the European Medicines Agency (EMA). POST-MARKET RESEARCH ? The drug has been used widely and has positive reviews from many studies. ? Novatis has since engaged in the phase II JULIET and the phase II ELIANA study clinical trials (Pharma US, 2017). ? The studies were conducted in 27 sites in 10 countries across Europe and Australia and North America. ? The studies revealed that patients were prone to suffer from hypogammaglobulinemia after using KYMRIAH (Novartis, 2018). ? This is a condition where their bodies immunity weakens, leading to numerous other diseases (Pharma US, 2017). ? To avoid this, patients can be given immunoglobulin to help and boost their immunity levels. ? The outlook is particularly bright in the use of CAR-T cell therapy. ? It is expected that more cancer illnesses can be treated in this manner in future (BioPharm International, 2017). REFERENCES International . (2017, August 30). FDA Approves Novartis’ CAR-T Drug, First Gene Therapy Approval in US. Retrieved from BioPharm : http://www.biopharminternational.com/fda-approves-novartis-car-t-drug-firstgene-therapy-approval-us ? BioPharm ? Novartis . (2018, January 17). Novartis granted US FDA Priority Review for Kymriah(TM) (tisagenlecleucel), formerly CTL019, for adults with r/r DLBCL. Retrieved from Novartis : https://www.novartis.com/news/mediareleases/novartis-granted-us-fda-priority-review-kymriahtm-tisagenlecleucelformerly-ctl019-adults-rr-dlbcl ? Pharma US. (2017). KYMRIAH. Retrieved from Novartis : https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/ky mriah.pdf … Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Pressing issues in the healthcare sector that will impact financial administrators Pressing issues in the healthcare sector that will impact financial administrators There have been many pressing issues in the healthcare sector that will impact financial administrators in the years ahead. Assignment: In a well- organized, focused essay, consider the importance of a financial issue in healthcare policy and its impact on the future of healthcare in the United States. Integrate at least three other sources from peer reviewed academic journals using APA editorial style. Length Requirement: 5 to 7 pages ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS You must proofread your paper. But do not strictly rely on your computer’s spell-checker and grammar-checker; failure to do so indicates a lack of effort on your part and you can expect your grade to suffer accordingly. Papers with numerous misspelled words and grammatical mistakes will be penalized. Read over your paper – in silence and then aloud – before handing it in and make corrections as necessary. Often it is advantageous to have a friend proofread your paper for obvious errors. Handwritten corrections are preferable to uncorrected mistakes. Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages. Likewise, large type, large margins, large indentations, triple-spacing, increased leading (space between lines), increased kerning (space between letters), and any other such attempts at “padding” to increase the length of a paper are unacceptable, wasteful of trees, and will not fool your professor. The paper must be neatly formatted, double-spaced with a one-inch margin on the top, bottom, and sides of each page. When submitting hard copy, be sure to use white paper and print out using dark ink. If it is hard to read your essay, it will also be hard to follow your argument. Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

UTA BE 4382 Electrogastrography Detecting Electrical Activities & Processes Lab ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ON UTA BE 4382 Electrogastrography Detecting Electrical Activities & Processes Lab Hello, I need someone to write me a lab report about this experiment. This requires various equipment. You must be able do PERL programming. please pick the question if you can help. I have attached everything from notes to date and sample lab report in the bottom of this question. attachment_1 attachment_2 attachment_3 attachment_4 attachment_5 Updated 2.27.12 BSL PRO Lesson H34: Electrogastrogram From a Human Subject This PRO Lesson describes how to record an electrogastrogram (electrical activity from the stomach muscles) from a resting human subject. All data collection and analysis is done via the Biopac Student Lab PRO software. Objectives 1. To record EGG from a human subject using surface electrodes. 2. Analyze the frequency of the signal using a Fast Fourier Transform. 3. Optional: The subject will eat a meal and record the EGG signal before and after eating. Overview In a healthy individual, the stomach muscles contract at regular intervals, giving a rhythmic electrical signal that is recorded by the electrodes. In a healthy subject at rest, the rhythm of the contraction is approximately three cycles per minute (.05 Hz). The power and frequency of the signal changes after a subject eats a meal. Students will place three disposable surface electrodes on the surface of the abdomen above the stomach to record the electrogastrogram (electrical activity from the stomach muscles) from a fasting human subject and, if desired, after eating. ? Read more about the electrogastrogram at MedicineNet.com Equipment ? BIOPAC electrode lead set (SS2L) ? BIOPAC electrodes (EL503)—three per subject ? Electrode gel and abrasive pad (BIOPAC GEL1 and ELPAD) ? Computer running Windows XP or Mac OS X ? Biopac Student Lab PRO software (BSL 3.7.3 or higher) ? BIOPAC Hardware (MP36, MP35 or MP45) www.biopac.com Page 1 of 5 BSL PRO Lesson H34 BIOPAC Systems, Inc. Setup Hardware 1. Turn your computer ON. ? If using an MP36/35 unit, turn it OFF. ? If using an MP45, make sure USB cable is connected and “Ready” light is ON. 2. Plug the Electrode Lead (SS2L) into CH 2. 3. Turn ON MP36/MP35 unit. Software 1. Launch the BSL PRO software. 2. Open the template file by choosing File menu > Open > choose Files of type: Graph Template (*GTL) > File Name: h34.gtl or H34 Electrogastrogram.gtl Calibration ? None required. Subject 1. Prepare the subject. For best results a. Remove all substantial metal jewelry from the Subject. b. Make sure that the Subject is not touching any metal (metal pipes, chairs etc.). c. Clean and abrade skin around electrode sites. ? If the skin is oily, clean electrode sites with soap and water or alcohol before abrading. d. Apply a drop of gel to each electrode. 2. Place three EL503 disposable surface electrodes on the Subject as indicated below. Electrode Position a. Place two electrodes on either side of the upper abdomen above the stomach. b. Place a third electrode above one of the first two. Lead Color RED Top (side with two electrodes) BLACK Bottom (side with two electrodes) WHITE Opposite (side with one electrode) 3. Attach the SS2L electrode leads by color as indicated above. ? The pinch connectors work like small clothes pins; however they will attach to the electrode only on one side. You may have to rotate the pin to make sure the metal on the inside of the clip is connected, touching, and clamped onto the electrode at the base of the nipple. ? Clip connector cables to subject’s clothing, or place so that there is no strain on the electrode clips or the cable wires at any point in the set up. 4. Turn on the MP unit. www.biopac.com Page 2 of 5 BSL PRO Lesson H34 BIOPAC Systems, Inc. 5. Subject gets in a supine position, with eyes closed. It is important that Subject is completely still during the recording. 6. Wait 5 minutes after the electrodes have been attached to the skin to begin recording (this gives the gel time to settle and maximize conductivity). Recording 1. Click the Start button to begin recording. UTA BE 4382 Electrogastrography Detecting Electrical Activities & Processes Lab 2. Record at least 10 minutes of continuous EGG data from the Subject at rest and then click Stop. o A clinical EGG normally takes 2-3 hours (to record fasting and after a meal), but you can see the essential characteristics of an EGG recording in much less time. o The template is set for 60 minutes of recording, but it can be lengthened or shortened as desired. 3. Optional: Ask the Subject to sit up and eat some food. After eating, the Subject should lie down and relax. 4. Click Start to begin recording. 5. Record at least 10 minutes of continuous EGG data from the Subject after eating and then click Stop. The following shows sample data. Note that the first 30 seconds of data is not valid as the filters are settling. Sample Data www.biopac.com Page 3 of 5 BSL PRO Lesson H34 BIOPAC Systems, Inc. Analysis 1. To make sure all data is shown, select Display > “Autoscale Horizontal” followed by Display > “Autoscale Waveforms”. 2. Select an area of data (using I-beam tool) that does not include the filter settling time (approx. first 30 seconds). Note: If multiple recordings (segments) were performed (i.e. before and after eating), only select data in the first recording. An append event marker ( ) is displayed at the start of each recording. Sample Data Selection 3. Select FFT from the Transform menu. 4. Select “Pad with zeros”, “Remove mean”, “Magnitude”, “Linear”, “Remove trend”, and “Window Hamming”, and then click OK. FFT Dialog Selections 5. The system will perform an FFT over the selected region of data. 6. In the FFT graph, zoom in on the frequencies of interest (0 to approx. 0.5 Hz.) www.biopac.com Page 4 of 5 BSL PRO Lesson H34 BIOPAC Systems, Inc. Zoom in on frequencies of interest 7. Set the first measurement box for “F@Max” (Frequency at maximum amplitude) from the pull-down menu. 8. Select an area that encompasses the maximum amplitude and record the measurement “F@Max”. Note that the frequency units will vary depending on software used. In the example below, the units are in “mHz” which is milli-Hertz. The measurement should be close to .05 Hz (50 mHz), which represents three contractions per minute. Frequency at Maximum measurement 9. If you performed the test before and after eating, repeat the analysis for the second recording segment. o You should notice a change in amplitude and frequency. www.biopac.com Page 5 of 5 Electrogastrography BE 5382 11th February, 2014 Food Processing Components of the Digestive System Gastrointestinal tract (GI) is a continuous tube that consists of the mouth, pharynx, esophagus, stomach, small intestine, large intestine, and anus. The lumen of this tube is continuous with the external environment. The accessory organs are the salivary glands, exocrine glands, and biliary system (liver and gallbladder). Digestive Tract Sructure ? mucosa – luminal surface. ? inner epithelial layer has exocrine and endocrine cells. ? middle lamina propria is connective tissue. ? muscularis mucosa is sparse layer of smooth muscle. ? ? ? submucosa – under the mucosa – large blood and lymph vessels. muscularis externa – between sub mucosa & serosa (outer layer) – an inner circular and outer longitudinal layer – contractions produce the propulsive and mixing movements. UTA BE 4382 Electrogastrography Detecting Electrical Activities & Processes Lab myenteric plexus – between the two smooth muscle layers – innervates stomach wall. Functions of the digestive system ? ? ? ? ? MOTILITY – movement of food through the digestive tract (ingestion, mastication, deglutition, peristalsis). SECRETION – both exocrine (water, acids, enzymes) and endocrine (gastrin, cholecystokinin, secretrin). DIGESTION – the breakdown of food molecules into their smaller absorbable subunits ABSORPTION – passage of digested end products into the blood or lymph. STORAGE & ELIMINATION – temporary storage and subsequent elimination of indigestible food molecules. GI Problems & Their Diagnosis ? GI Problems: ? ? ? ? ? Nausea Gastric Reflux Peptic Ulcer Irritable Bowel Syndrome Cirrhosis ? Clinical methods: – Electrogastrography; ?-raying methods; Endoscopy. – – What is EGG? ? Like ECG & heart Measures muscle activity related to the stomach and abdominal region. ? Measured from a baseline reading containing a regular rhythm. In a normal subject a current increase is observed after a meal. ? Still an early experimental procedure because it has yet to become a standard medical procedure. ? ECG electrodes are typically used ? Physiological Basis of EGG ? GI tract motility is a result of 2 complementary rhythms ? ? ? Slow wave activity ? smooth muscle contraction timing Electrical response activity ? peristaltic contractions Recognized in cells of the distal 2/3rd of the stomach Information from EGG ? ? ? Normal EGG has regular rhythm (similar to ECG) Electrical activity increases after meal No increase in case of abnormalities Gastric Activity ? ? ? ? ? Large intestine Stomach Ileum Jejunum Duodenum Freq. (Hz) Waves/min 0.01 – 0.3 0.03 – 0.07 0.07 – 0.13 0.13 – 0.18 0.18 – 0.25 2-17 3 8 11 12 Duodenum: Latin, duodeni ‘in twelves’ (approx. twelve fingers across) Jejunum: Latin, jejunus ‘fasting’ Ileum: Latin, ilia ‘flanks, entrails’ Gastric Alterations ? Bradygastria: < 2 cycles/min, 1 minute ? Tachygastria: > 4 cycles/min, 1 minute ? Associated with nausea, gastroparesis, irritable bowel syndrome, and functional dyspepsia Capabilities of EGG ? Slight increase in gastric frequency obtained after feeding. ? Frequency is the most reliable parameter for clinical applications. ? Recorded deviations will be related to gastric electrical abnormalities. Limitations of EGG ? ? ? ? Data obtained is difficult to analyze and abnormalities difficult to define. Interference from the duodenum and from the transverse and descending colon. Absence of standard technique or standard norms Noise must be reduced Experimental Objective ? ? ? To record EGG from a human subject using surface electrodes. Analyze the frequency of the signal using a Fast Fourier Transform. UTA BE 4382 Electrogastrography Detecting Electrical Activities & Processes Lab The subject will eat a meal and record the EGG signal before and after eating. Materials and Set Up • Biopac Materials : • Transducers: SS2L (Electrode lead set) • Disposable vinyl electrodes (EL503), Electrode gel (GEL1) • Acquisition unit (MP30), • Student Lab software v3.6.7 PC • Wall transformer (AC100A), serial cable (CBLSERA) or USB cable (USB1W) Recording ? ? ? ? BSL PRO – Open h34.gtl file (Z:) Subject relaxed and lying in supine position quietly, face upward (Minimal Body Movements to avoid EMG artifacts) Record at least 10 minutes of continuous EGG (no calibration) Ask the Subject to sit up and eat some food. After eating, the Subject should lie down and relax. Record for 10 minutes Analysis 1. Select a section of the raw EGG data by highlighting it with the I-beam tool. 2. Select FFT from the Analysis menu. 3. Select Remove mean, Remove trend, and Linear, and then click OK. FFT You will see a peak of activity close to .05 Hz, which represents three contractions per minute Repeat the analysis for the second segment. You should notice a change in amplitude and frequency Group: Subject: Hours after last meal: Gender: maxF(Hz) amplitude (mV) Baseline (lying down) (15 minutes) Reading 1 After intake (30 minutes) Reading 2 Analysis: Follow steps 1 to 8 from the procedure document, for each segment Remember FFT is under the Analysis tab Group: Subject: Hours after last meal: Gender: maxF(Hz) amplitude (mV) Baseline (lying down) (15 minutes) Reading 1 After intake (30 minutes) Reading 2 Analysis: Follow steps 1 to 8 from the procedure document, for each segment Remember FFT is under the Analysis tab BME 4382 Laboratory Principles, Spring 2016 Lab Title: Put the appropriate title Author Name: The one who is writing the report Experiment Date: When you conducted the study Submission Date: The date you submitted the report Subject Names: On whom the study was conducted Observer Names: Those who took the readings … Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Analyze a firms capital structure and its impact on firm performance Analyze a firms capital structure and its impact on firm performance The purpose of this assignment is to analyze a firm’s capital structure and its impact on firm performance. Within the assignment, explain core concepts related to business risk and recommend sound financial decisions based on analysis of a firm’s capital structure and capital budgeting techniques. ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS Read the Chapter 15 Mini Case in Financial Management : Theory and Practice. Using complete sentences and academic vocabulary, please answer questions a and b (both attached). Using the mini case information, write a 300-500 word recommendation of the financial decisions you propose for this company based on an analysis of its capital structure and capital budgeting techniques. Explain why you chose this recommendation. While APA style is not required for the body of this assignment, solid academic writing is expected, and documentation of sources should be presented using APA formatting guidelines. This assignment uses a rubric. Please review the rubric prior to beginning the assignment to become familiar with the expectations for successful completion. ****You will be graded on (Rubric): 1. Question A: Answer to question A is extremely thorough and supported with substantial relevant details. 2. Question B: Answer to question B is extremely thorough and supported with substantial relevant details. 3 Analysis of Firm\\\’s Capital Structure and Impact on Performance (C5.1): An analysis of a firm\\\’s capital structure and its impact on the firm\\\’s performance is extremely thorough and supports with substantial relevant details. 4. Financial Decisions (C3.1; C9.1): Recommendations for proposed financial decisions based on analysis of capital structure and capital budgeting techniques are extremely thorough and include substantial supporting details and examples. 5. Mechanics of Writing (includes spelling, punctuation, grammar, and language use): The writer is clearly in command of standard, written, academic English. Answer preview to analyze a firm’s capital structure and its impact on firm performance. Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Discussion: Art of Web Development Research ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ON Discussion: Art of Web Development Research Develop and submit the Introduction section of your research paper. This section of your research paper should … Widener University CMSM 498 Art of Web Development Research Be 2 pages in length Discussion: Art of Web Development Research Include the following sub-sections … Statement of the problem Purpose of the research Relevance and significance Conform to APA format, especially citations and references. Typed using Times New Roman font, 12 point with one-inch margins. I will provide you with a full explanation along with my paper and examples to get this assignment perfectly done. You must proofread your paper. But do not strictly rely on your computer’s spell-checker and grammar-checker; failure to do so indicates a lack of effort on your part and you can expect your grade to suffer accordingly. Papers with numerous misspelled words and grammatical mistakes will be penalized. Read over your paper – in silence and then aloud – before handing it in and make corrections as necessary. Often it is advantageous to have a friend proofread your paper for obvious errors. Handwritten corrections are preferable to uncorrected mistakes. Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages. Likewise, large type, large margins, large indentations, triple-spacing, increased leading (space between lines), increased kerning (space between letters), and any other such attempts at “padding” to increase the length of a paper are unacceptable, wasteful of trees, and will not fool your professor. The paper must be neatly formatted, double-spaced with a one-inch margin on the top, bottom, and sides of each page. When submitting hard copy, be sure to use white paper and print out using dark ink. If it is hard to read your essay, it will also be hard to follow your argument. ADDITIONAL INSTRUCTIONS FOR THE CLASS Discussion Questions (DQ) Initial responses to the DQ should address all components of the questions asked, include a minimum of one scholarly source, and be at least 250 words. Successful responses are substantive (i.e., add something new to the discussion, engage others in the discussion, well-developed idea) and include at least one scholarly source. One or two sentence responses, simple statements of agreement or “good post,” and responses that are off-topic will not count as substantive. Substantive responses should be at least 150 words. I encourage you to incorporate the readings from the week (as applicable) into your responses. Weekly Participation Your initial responses to the mandatory DQ do not count toward participation and are graded separately. In addition to the DQ responses, you must post at least one reply to peers (or me) on three separate days, for a total of three replies. Participation posts do not require a scholarly source/citation (unless you cite someone else’s work). Part of your weekly participation includes viewing the weekly announcement and attesting to watching it in the comments. These announcements are made to ensure you understand everything that is due during the week. APA Format and Writing Quality Familiarize yourself with APA format and practice using it correctly. It is used for most writing assignments for your degree. Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for APA paper templates, citation examples, tips, etc. Points will be deducted for poor use of APA format or absence of APA format (if required). Cite all sources of information! When in doubt, cite the source. Paraphrasing also requires a citation. I highly recommend using the APA Publication Manual, 6th edition. Use of Direct Quotes I discourage overutilization of direct quotes in DQs and assignments at the Masters’ level and deduct points accordingly. As Masters’ level students, it is important that you be able to critically analyze and interpret information from journal articles and other resources. Simply restating someone else’s words does not demonstrate an understanding of the content or critical analysis of the content. It is best to paraphrase content and cite your source. LopesWrite Policy For assignments that need to be submitted to LopesWrite, please be sure you have received your report and Similarity Index (SI) percentage BEFORE you do a “final submit” to me. Once you have received your report, please review it. This report will show you grammatical, punctuation, and spelling errors that can easily be fixed. Take the extra few minutes to review instead of getting counted off for these mistakes. Review your similarities. Did you forget to cite something? Did you not paraphrase well enough? Is your paper made up of someone else’s thoughts more than your own? Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for tips on improving your paper and SI score. Late Policy The university’s policy on late assignments is 10% penalty PER DAY LATE. This also applies to late DQ replies. Discussion: Art of Web Development Research Please communicate with me if you anticipate having to submit an assignment late. I am happy to be flexible, with advance notice. We may be able to work out an extension based on extenuating circumstances. If you do not communicate with me before submitting an assignment late, the GCU late policy will be in effect. I do not accept assignments that are two or more weeks late unless we have worked out an extension. As per policy, no assignments are accepted after the last day of class. Any assignment submitted after midnight on the last day of class will not be accepted for grading. Communication Communication is so very important. There are multiple ways to communicate with me: Discussion: Art of Web Development Research Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class. Individual Forum: This is a private forum to ask me questions or send me messages. This will be checked at least once every 24 hours. Widener University CMSM 498 Art of Web Development Research Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Assignment: Acquired Immunodeficiency Syndrome ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ON Assignment: Acquired Immunodeficiency Syndrome A major problem that makes the development of successful programs very difficult to help welfare recipients, AIDS patients, and the homeless is the diversity of values and points of view regarding the most effective ways of dealing with these groups. This factor leads to the problem of funding programs for these and other needy populations. Take a look at the scenario below – Which answer would you choose? Assignment: Acquired Immunodeficiency Syndrome A human services agency is trying to come up with a practice to prevent the spread of AIDS among youth. The agency is struggling to come to a conclusion and decide on a specific practice. According to you, what is the best way to deal with the AIDS epidemic? 1. Isolating victims from the uninfected population. 2. Banning infected individuals from engaging in sexual activities. 3. Distributing contraceptives in high schools and colleges as a form of prevention. Write a 3-4 page paper in which you: Think about the impact of policies and programs on diverse populations. What are the agency responsibilities and issues that may arise as a result of your choice? What is the role of analysis in meeting the needs of this diverse population? What factors did you consider in making a choice? What alternative solution would you suggest for prevention of the epidemic? How might new approaches for addressing the needs of this population impact service delivery from various point of views (provider, agency, recipient)? What role do the three levels of prevention play in developing a new approach? What factors must be taken into consideration when developing prevention practices, techniques, and programs within an ecological systems context? This essay must follow all APA style (Links to an external site.) formatting requirements. For further guidelines on your paper, refer to the Essay Rub ric (see attachment) RESOURCES: Recommendations for Developing Contextually Relevant HIV-AIDS Prevention Strategies (see attachment) Sexual Safety Panning as an HIV Prevention Strategy (see attachment) attachment_1 attachment_2 attachment_3 Unsatisfactory 0-12 Emerging 13-14 Satisfactory 15-16 Proficient 17-18 Distinguished 19-20 Organization Information is unorganized, incomplete, or completely lacking in evidence. Somewhat organized presentation of information and evidence. Opening statement minimally outlines major points; closing argument briefly restates the ideas offered in the opening statement. Organized and generally complete presentation of information and evidence. Opening statement outlines or lists major points and evidence but does not generate interest; closing statement does not reflect main ideas. Well-organized and complete presentation of information and evidence. Opening statement successfully frames the essay; closing statement summarizes main ideas. Extremely thorough, well-organized presentation of information and evidence. Opening statement engages the interest of audience; closing statement leaves no unanswered issues and resonates with the audience. Quality of Information Information has nothing to do with main topic, social problem, and/or theory. Information has little to do with the main topic, social problem and/or theory. Possibly vague or illogical information provided. Information adequately relates to the main topic. Information mostly relates to the main topic. Information clearly relates to the main topic. Effective use of historical evidence /content knowledge Demonstrates an inadequate understanding of the history/ content relevant to the topic. Supports statements with vague or irrelevant information or no information at all. Demonstrates a generally accurate understanding of relevant issues, events and facts, but may exhibit minor confusion or misunderstandings. Seems to understand general ideas, but does not support ideas with relevant facts; OR, seems to understand facts but is unable to connect them into coherent arguments. Demonstrates a basic and accurate understanding of the issues, events and facts relevant to the topic. Demonstrates the ability to make basic connections between facts and concepts. Demonstrates a sophisticated understanding of the issues, events and facts relevant to the topic. Demonstrates thorough and accurate understanding of details as well as the ability to make original connections and interpretations. Demonstrates a sophisticated understanding of the issues, events, and facts relevant to the topic. Demonstrates thorough and accurate understanding of details as well as the ability to make original connections and interpretations. Fewer than 10 mechanics, spelling, usage, grammar or punctuation errors. Exceeds 8 grammatical and/or punctuation errors. Between 6 and 8 grammatical and/or punctuation errors. Between 3 and 5 grammatical and/or punctuation errors. 1-2 grammatical and/or punctuation errors, but they are minor and do not detract from the essay. No errors whatsoever! APA-style cover sheet, citations, and references; Appropriately uses in-text citations in APA style formatting. Fails to meet these criteria with 8+ exceptions. Fails to meet these criteria with 6-8 exceptions. Does not meet these criteria with 3-5 exceptions. Meets these criteria with only 1-2 minor exceptions. Exceeds these criteria by completely meeting ALL of these requirements with NO exceptions! Assignment: Acquired Immunodeficiency Syndrome Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Accident Investigation Organizations from Around the World Accident Investigation Organizations from Around the World Accident Investigation Organizations from Around the World This assignment will present you with the opportunity to explore different governmental organizations around the world, similar to the NTSB responsible for accident investigation . Each person/team chooses a country to research. From your research, you will formulate a brief 3-5 page paper discussing the organization from your country. At a minimum, your presentation should discuss the history, mission, organizational structure, and accident investigation policies/procedures of the organization (Simply cutting and pasting from an internet site will earn a failing grade!!) Grading rubric is same as final paper rubric. Some countries that will work well are: Singapore Australia____________ Canada United Kingdom ____________France New Zealand ____________ United Arab Emirates Netherlands Japan ____________Germany Iceland ____________South Africa Malaysia ____________Ireland Taiwan Requirements: Essay | 3 pages, Double spaced ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS Answer preview to Accident Investigation Organizations from Around the World You must proofread your paper. But do not strictly rely on your computer’s spell-checker and grammar-checker; failure to do so indicates a lack of effort on your part and you can expect your grade to suffer accordingly. Papers with numerous misspelled words and grammatical mistakes will be penalized. Read over your paper – in silence and then aloud – before handing it in and make corrections as necessary. Often it is advantageous to have a friend proofread your paper for obvious errors. Handwritten corrections are preferable to uncorrected mistakes. Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages. Likewise, large type, large margins, large indentations, triple-spacing, increased leading (space between lines), increased kerning (space between letters), and any other such attempts at “padding” to increase the length of a paper are unacceptable, wasteful of trees, and will not fool your professor. The paper must be neatly formatted, double-spaced with a one-inch margin on the top, bottom, and sides of each page. When submitting hard copy, be sure to use white paper and print out using dark ink. If it is hard to read your essay, it will also be hard to follow your argument. Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Ethics in Health Care Practices Ethics in Health Care Practices Write a 250 words summary essay. Please include a Title Page, Conclusion, and References. Select any topic of your preference related to Ethics in Health Care , using any article from the internet, textbooks, newspapers, magazines, research papers, etc. Requirements: 250 words ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS Answer preview to select any topic of your preference related to Ethics in Health Care You must proofread your paper. But do not strictly rely on your computer’s spell-checker and grammar-checker; failure to do so indicates a lack of effort on your part and you can expect your grade to suffer accordingly. Papers with numerous misspelled words and grammatical mistakes will be penalized. Read over your paper – in silence and then aloud – before handing it in and make corrections as necessary. Often it is advantageous to have a friend proofread your paper for obvious errors. Handwritten corrections are preferable to uncorrected mistakes. Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages. Likewise, large type, large margins, large indentations, triple-spacing, increased leading (space between lines), increased kerning (space between letters), and any other such attempts at “padding” to increase the length of a paper are unacceptable, wasteful of trees, and will not fool your professor. The paper must be neatly formatted, double-spaced with a one-inch margin on the top, bottom, and sides of each page. When submitting hard copy, be sure to use white paper and print out using dark ink. If it is hard to read your essay, it will also be hard to follow your argument. ADDITIONAL INSTRUCTIONS FOR THE CLASS Discussion Questions (DQ) Initial responses to the DQ should address all components of the questions asked, include a minimum of one scholarly source, and be at least 250 words. Successful responses are substantive (i.e., add something new to the discussion, engage others in the discussion, well-developed idea) and include at least one scholarly source. One or two sentence responses, simple statements of agreement or “good post,” and responses that are off-topic will not count as substantive. Substantive responses should be at least 150 words. I encourage you to incorporate the readings from the week (as applicable) into your responses. Weekly Participation Your initial responses to the mandatory DQ do not count toward participation and are graded separately. In addition to the DQ responses, you must post at least one reply to peers (or me) on three separate days, for a total of three replies. Participation posts do not require a scholarly source/citation (unless you cite someone else’s work). Part of your weekly participation includes viewing the weekly announcement and attesting to watching it in the comments. These announcements are made to ensure you understand everything that is due during the week. APA Format and Writing Quality Familiarize yourself with APA format and practice using it correctly. It is used for most writing assignments for your degree. Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for APA paper templates, citation examples, tips, etc. Points will be deducted for poor use of APA format or absence of APA format (if required). Cite all sources of information! When in doubt, cite the source. Paraphrasing also requires a citation. I highly recommend using the APA Publication Manual, 6th edition. Use of Direct Quotes I discourage overutilization of direct quotes in DQs and assignments at the Masters’ level and deduct points accordingly. As Masters’ level students, it is important that you be able to critically analyze and interpret information from journal articles and other resources. Simply restating someone else’s words does not demonstrate an understanding of the content or critical analysis of the content. It is best to paraphrase content and cite your source. LopesWrite Policy For assignments that need to be submitted to LopesWrite, please be sure you have received your report and Similarity Index (SI) percentage BEFORE you do a “final submit” to me. Once you have received your report, please review it. This report will show you grammatical, punctuation, and spelling errors that can easily be fixed. Take the extra few minutes to review instead of getting counted off for these mistakes. Review your similarities. Did you forget to cite something? Did you not paraphrase well enough? Is your paper made up of someone else’s thoughts more than your own? Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for tips on improving your paper and SI score. Late Policy The university’s policy on late assignments is 10% penalty PER DAY LATE. This also applies to late DQ replies. Please communicate with me if you anticipate having to submit an assignment late. I am happy to be flexible, with advance notice. We may be able to work out an extension based on extenuating circumstances. If you do not communicate with me before submitting an assignment late, the GCU late policy will be in effect. I do not accept assignments that are two or more weeks late unless we have worked out an extension. As per policy, no assignments are accepted after the last day of class. Any assignment submitted after midnight on the last day of class will not be accepted for grading. Communication Communication is so very important. There are multiple ways to communicate with me: Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class. Individual Forum: This is a private forum to ask me questions or send me messages. This will be checked at least once every 24 hours. Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Articulate and illustrate the cultural social and historical influences on the definition of family Articulate and illustrate the cultural social and historical influences on the definition of family Introduction Provide a thoughtful definition of what family means to you (do not copy the text). ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ULOs Articulate and illustrate the cultural social and historical influences on the definition of family (CLO2) Directions In 200 words or more, write your definition of family. Please do not copy a definition from the textbook, dictionary, or online website. This definition must be your own. Requirements: at least 2 pages Answer preview to articulate and illustrate the cultural social and historical influences on the definition of family You must proofread your paper. But do not strictly rely on your computer’s spell-checker and grammar-checker; failure to do so indicates a lack of effort on your part and you can expect your grade to suffer accordingly. Papers with numerous misspelled words and grammatical mistakes will be penalized. Read over your paper – in silence and then aloud – before handing it in and make corrections as necessary. Often it is advantageous to have a friend proofread your paper for obvious errors. Handwritten corrections are preferable to uncorrected mistakes. Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages. Likewise, large type, large margins, large indentations, triple-spacing, increased leading (space between lines), increased kerning (space between letters), and any other such attempts at “padding” to increase the length of a paper are unacceptable, wasteful of trees, and will not fool your professor. The paper must be neatly formatted, double-spaced with a one-inch margin on the top, bottom, and sides of each page. When submitting hard copy, be sure to use white paper and print out using dark ink. If it is hard to read your essay, it will also be hard to follow your argument. ADDITIONAL INSTRUCTIONS FOR THE CLASS Discussion Questions (DQ) Initial responses to the DQ should address all components of the questions asked, include a minimum of one scholarly source, and be at least 250 words. Successful responses are substantive (i.e., add something new to the discussion, engage others in the discussion, well-developed idea) and include at least one scholarly source. One or two sentence responses, simple statements of agreement or “good post,” and responses that are off-topic will not count as substantive. Substantive responses should be at least 150 words. I encourage you to incorporate the readings from the week (as applicable) into your responses. Weekly Participation Your initial responses to the mandatory DQ do not count toward participation and are graded separately. In addition to the DQ responses, you must post at least one reply to peers (or me) on three separate days, for a total of three replies. Participation posts do not require a scholarly source/citation (unless you cite someone else’s work). Part of your weekly participation includes viewing the weekly announcement and attesting to watching it in the comments. These announcements are made to ensure you understand everything that is due during the week. APA Format and Writing Quality Familiarize yourself with APA format and practice using it correctly. It is used for most writing assignments for your degree. Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for APA paper templates, citation examples, tips, etc. Points will be deducted for poor use of APA format or absence of APA format (if required). Cite all sources of information! When in doubt, cite the source. Paraphrasing also requires a citation. I highly recommend using the APA Publication Manual, 6th edition. Use of Direct Quotes I discourage overutilization of direct quotes in DQs and assignments at the Masters’ level and deduct points accordingly. As Masters’ level students, it is important that you be able to critically analyze and interpret information from journal articles and other resources. Simply restating someone else’s words does not demonstrate an understanding of the content or critical analysis of the content. It is best to paraphrase content and cite your source. LopesWrite Policy For assignments that need to be submitted to LopesWrite, please be sure you have received your report and Similarity Index (SI) percentage BEFORE you do a “final submit” to me. Once you have received your report, please review it. This report will show you grammatical, punctuation, and spelling errors that can easily be fixed. Take the extra few minutes to review instead of getting counted off for these mistakes. Review your similarities. Did you forget to cite something? Did you not paraphrase well enough? Is your paper made up of someone else’s thoughts more than your own? Visit the Writing Center in the Student Success Center, under the Resources tab in LoudCloud for tips on improving your paper and SI score. Late Policy The university’s policy on late assignments is 10% penalty PER DAY LATE. This also applies to late DQ replies. Please communicate with me if you anticipate having to submit an assignment late. I am happy to be flexible, with advance notice. We may be able to work out an extension based on extenuating circumstances. If you do not communicate with me before submitting an assignment late, the GCU late policy will be in effect. I do not accept assignments that are two or more weeks late unless we have worked out an extension. As per policy, no assignments are accepted after the last day of class. Any assignment submitted after midnight on the last day of class will not be accepted for grading. Communication Communication is so very important. There are multiple ways to communicate with me: Questions to Instructor Forum: This is a great place to ask course content or assignment questions. If you have a question, there is a good chance one of your peers does as well. This is a public forum for the class. Individual Forum: This is a private forum to ask me questions or send me messages. This will be checked at least once every 24 hours. Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

Principles to Safety Management Concepts Questions ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ON Principles to Safety Management Concepts Questions Question 1 A manufacturing facility that makes steel materials handling devices such as hand carts and an assortment of roller carts for moving heavy materials around in manufacturing facilities has decided to start making cantilever storage racking systems. This will require the purchase and installation of a 12-foot hydraulic press brake and a 12-foot shear in the fabrication department along with the necessary tools and dies to bend and punch holes in the rack components that will largely be manufactured from formed sheet metal. Employees have experience working smaller versions of this type of equipment, but room will need to be made and larger pieces of sheet metal will need to be cut and handled. The department will also need to continue to produce existing orders while the new equipment is installed. How can a management of change program be used to reduce risks in such a scenario? Principles to Safety Management Concepts Questions Your response must be at least 75 words in length. Question 2 Your organization, a company that manufactures fitness equipment such as treadmills and elliptical machines, is about to introduce lean concepts into its operations in order to be more competitive with foreign manufacturers. The foreman from the assembly department, however, does not think that his employees have the time to be involved with the lean initiative. Provide a convincing argument about why it is important for the assembly line workers to play a part. Your response must be at least 75 words in length. Question 3 Your purchasing department does not want to buy adjustable hydraulic pallet stands for the filter assembly line at a company that makes oil filters for cars and trucks. They state that the current process works just fine and that expensive, adjustable stands are not required in the Occupational Health and Safety Administration standards. The production employees in the facility are largely female and many have worked at the facility for decades. The current process for accessing filter parts entails having assemblers bend over to pick up arm loads of the various filter components from a pallet or bin and placing them on a table beside their respective workstations. The parts are assembled and pressed into place, and the completed product placed in a separate bin. Please provide a risk-based argument as to why the adjustable pallet stands would be the better choice. Your response must be at least 200 words in length. attachment_1 Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10